The duration of tilmicosin premix has an important impact on the arrangement of its treatment plans, which is mainly reflected in the following aspects:
1. Long duration of efficacy and reduced frequency of administration
After oral administration, tilmicosin premix is rapidly absorbed, has strong tissue penetration, large distribution volume, high concentration in the lungs, an elimination half-life of up to 1~2 days, and a long maintenance time of effective blood drug concentration. This feature enables tilmicosin premix to maintain an effective concentration for a long time during treatment, thereby reducing the frequency of administration. Compared with drugs that require frequent administration, tilmicosin premix is more convenient to use and improves the convenience of treatment.
2. Formulate a reasonable medication cycle
Due to the long duration of tilmicosin premix, veterinarians can calculate a reasonable medication cycle and dosage based on the animal's condition and weight when formulating a treatment plan. For example, the Ministry of Agriculture stipulates that the dosage of tilmicosin is 200~400mg/kg mixed with feed, and it is recommended to use it continuously for 7~14 days. The common tilmicosin premix content on the market is 20%, that is, adding 1~2kg of 20% tilmicosin premix to each ton of feed can reach the recommended dose. This arrangement of the medication cycle can not only ensure that the drug maintains an effective concentration in the body, but also avoid drug abuse and waste.
3. Optimizing the therapeutic effect
The duration of the efficacy of tilmicosin premix is also closely related to its therapeutic effect. Since the drug can maintain an effective concentration in the body for a long time, it can better play an antibacterial role and inhibit the growth and reproduction of pathogens. At the same time, tilmicosin also has an antibacterial post-effect, which can continue to inhibit the reproduction of bacteria after discontinuation of the drug, which helps to consolidate the therapeutic effect and prevent recurrence of the disease.
4. Precautions and contraindications
When using tilmicosin premix, you also need to pay attention to some matters and contraindications. For example, the combination of tilmicosin and epinephrine can increase the risk of death in pigs. It has the same target as other macrolides and lincosamides, so it is not suitable to be used at the same time. In addition, since tilmicosin tastes bitter, if the stomach empties slowly, the drug will stay in the stomach for a long time, which will increase the irritation to the gastric mucosa and increase the risk of gastric ulcers. Therefore, when using it, the drug should be mixed with the feed after controlling the feeding time to shorten the drug's residence time in the stomach, thereby enhancing the efficacy and reducing damage to the gastric mucosa.
The duration of tilmicosin premix has an important impact on the arrangement of its treatment plan. When formulating a treatment plan, veterinarians should fully consider factors such as the duration of the drug's efficacy, medication cycle, treatment effect, precautions and incompatibility to ensure the rationality and effectiveness of the treatment plan.
