What are the advantages of albendazole and ivermectin premix in broadening the anthelmintic spectrum?
Publish Time: 2025-02-07
In livestock and poultry farming, parasitic diseases are a problem that cannot be ignored. It not only affects the health and growth performance of livestock and poultry, but may also cause serious economic losses. In order to effectively control parasitic diseases, farmers have been looking for highly effective and broad-spectrum anthelmintics. Albendazole and ivermectin premix, as an innovative anthelmintic solution, has been widely used in livestock and poultry farming due to its advantage of broadening the anthelmintic spectrum.
Albendazole and ivermectin premix combines two highly effective and broad-spectrum anthelmintic drug ingredients: albendazole and ivermectin. Albendazole is a broad-spectrum, highly effective and low-toxic anthelmintic belonging to the benzimidazole class. It works by inhibiting cellular tubulin and energy metabolism, especially by binding to tubulin, which is necessary for nutrient uptake in parasite cells, thereby interfering with protein polymerization in the microtubule configuration process, thereby killing parasites. Albendazole has a highly effective expelling effect on a variety of nematodes, and also has a strong effect on some flukes and tapeworms, but has a smaller effect on arthropods outside the body.
Ivermectin is a broad-spectrum, highly effective and low-toxic macrolide antibiotic anthelmintic with a unique mechanism of action. It mainly acts on the γ-aminobutyric acid (GABA) of the insect body, blocking nerve transmission and causing the death of the insect body. For arthropods, ivermectin can block the transmission between nerves and muscles, causing paralysis or death of the insect body. Therefore, it shows excellent expelling and killing effects on nematodes and parasitic arthropods. In addition, ivermectin can also reduce tick egg laying and make the nematode eggs in ruminants abnormal in morphology, thereby indirectly killing the eggs. However, it should be noted that since flukes and tapeworms do not rely on GABA for transmission, ivermectin is ineffective against them.
Premixing albendazole and ivermectin can give full play to the advantages of both and achieve complementary anthelmintic spectrum. This combination can not only effectively expel nematodes, trematodes and tapeworms, but also has a good expelling effect on external arthropods such as mites, ticks and flies. It covers almost 99% of parasite species, thus greatly broadening the spectrum of anthelmintics.
In summary, albendazole and ivermectin premix has significant advantages in broadening the spectrum of anthelmintics. It not only improves the anthelmintic effect, but also simplifies the anthelmintic operation and reduces the breeding cost. For livestock and poultry farmers, this is undoubtedly an ideal anthelmintic solution.
