Enrofloxacin solution, as a quinolone antibacterial drug, has shown excellent antibacterial effects in livestock and poultry farming and human medicine, especially in the treatment of bacterial diseases and mycoplasma infections.
1. Pharmacological properties
Enrofloxacin solution belongs to the fluoroquinolone broad-spectrum bactericidal drug. Its antibacterial mechanism is mainly through the inhibition of bacterial DNA gyrase, thereby interfering with the replication, transcription and repair recombination process of bacterial DNA, so that bacteria cannot grow and reproduce normally and die. The drug shows strong antibacterial activity against a variety of pathogens, including but not limited to Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelothrix, Proteus, Serratia marcescens, Corynebacterium pyogenes, Botella septicum, Staphylococcus aureus, Mycoplasma and Chlamydia. It is worth noting that enrofloxacin has relatively weak effects on Pseudomonas aeruginosa and Streptococcus, and its effects on anaerobic bacteria are also relatively limited.
2. Clinical application
Enrofloxacin solution is widely used in livestock and poultry farming to treat a variety of bacterial diseases and mycoplasma infections, including but not limited to:
Swine diseases: such as yellow and white diarrhea, red diarrhea, edema disease, swine dysentery, infectious gastroenteritis, epidemic diarrhea, paratyphoid, rotavirus disease, pleuropneumonia, parahaemophilus disease and other digestive and respiratory diseases.
Calves and lambs: used to treat diarrhea, dysentery, Escherichia coli disease, etc.
Chicken diseases: such as pullorum diarrhea, fowl cholera, chicken infectious rhinitis, chicken chronic respiratory disease, etc.
Rabbit diseases: including enteritis, diarrhea, bloody diarrhea, etc. in rabbits, especially in the early stage of the disease, the effect of enrofloxacin solution is remarkable.
Special breeding: Enrofloxacin is often used to treat diarrhea caused by bacterial enteritis, gastroenteritis and feed changes in animals such as foxes and minks.
In the field of human medicine, enrofloxacin solution (or its similar drugs) is used to treat diseases such as acute bacterial sinusitis, acute exacerbation of chronic bronchitis, community-acquired pneumonia, complicated intra-abdominal infection, complicated skin and skin structure infection caused by sensitive bacteria.
3. Usage and Dosage
The usage and dosage of enrofloxacin solution should be determined according to the specific condition and animal species. In livestock and poultry farming, common usages include mixed drinking and oral administration. When mixed drinking, 2-3 ml of poultry enrofloxacin solution can be added to every 1L of water for 3-5 consecutive days. When oral administration, the dosage should be calculated according to the weight of the animal, such as 1 ml for every 1kg of body weight for newborn piglets, and 4-8 doses for medium and large pigs.
4. Adverse Reactions and Precautions
Although enrofloxacin solution has significant efficacy, it is also necessary to pay attention to its possible adverse reactions during use, mainly including:
Skin reactions: such as rash, itching, erythema, etc., which generally recover on their own after stopping the drug.
Gastrointestinal reactions: such as diarrhea, nausea, vomiting, abdominal pain, etc., need to adjust the dosage or change the drug.
Central nervous system reactions: including dizziness, headache, drowsiness, insomnia, paresthesia, etc., which may induce epileptic seizures in severe cases.
Blood system reactions: may inhibit bone marrow hematopoietic function, leading to leukopenia, thrombocytopenia, anemia, etc.
In addition, the following matters should be noted:
Liver and kidney function should be tested regularly during medication to avoid drug damage.
Dietary adjustments should be made to avoid greasy and irritating foods.
The drug should be stored in a place where children are not allowed to touch it to avoid accidental ingestion.
As a highly effective quinolone antibacterial drug, enrofloxacin solution plays an important role in livestock and poultry farming and human medicine. Its broad-spectrum antibacterial activity and good bioavailability make it show excellent efficacy in the treatment of various bacterial diseases and mycoplasma infections. However, during use, it is also necessary to pay attention to its possible adverse reactions and strictly abide by the medication specifications to ensure safe and effective medication.
